The Effects of Novel Compounds on Cell Cycle Progression & Drug Sensitivity for the Malaria Parasite
Malaria is a tropical disease caused by an infection of the protozoan parasite, Plasmodium falciparum. Approximately 1.2 million deaths are attributed to malaria annually, and its morbidity and mortality is expected to increase as the parasite develops resistance to all known antimalarial drugs including the standard treatments containing artemisinin. Military force health protection planning emphasizes research designed to reduce malaria-associated mortality. To combat drug resistance, new chemical entities must be explored for drug discovery. Surprisingly, extensive anti-malarial drug development has been directed against the parasite yet there is a knowledge gap on how the parasite grows and dies.
The aim of this project is to identify and characterize compounds that target the cell cycle machinery of the parasite. Methodologies employed include malaria parasite cultivation, microscopy, flow cytometry, cell-based growth inhibition assays, enzymatic assays, protein expression and purification, immuno-blots, immunofluorescence and novel compound selection.
OCONUS AIAD opportunities aligned with this project : Research at the Australian Army Malaria Institute and US Army Medical Research Institute-Kenya. CONUS AIAD: the Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD
Point of Contact:
COL Carl Brinkley