Design and Synthesis of Caged Neurotransmitters
Understanding the specific malfunctions of the brain is necessary to develop cures for diseases and disorders such as Alzheimer’s and epilepsy. We are developing caged glutamate molecules which can be delivered to specific neuron sites in an inactive form. The cage can then be removed with a pin pointed laser (hv) releasing the active glutamate to attach to the specific site of study, leading to insight on how the brain network is affected. This will facilitate the understanding of neural diseases and potentially lead to the development of treatments.
Synthesis, characterization and analysis of fluorosulfanilamide derivatives
In collaboration with Dr. Joseph Sloop, Georgia Gwinnett College, we will seek to improve current sulfa drugs. Sulfa drugs are used in medicine as antimicrobial and antibacterial agents. By designing, synthesizing, and testing new analogues, we can potentially discover a more potent drug.
Synthesis, characterization and analysis of 1,2-indanedione derivatives
In collaboration with Dr. Joseph Sloop, Georgia Gwinnett College, selected di- and triketones derived from 1,2-indanedione will be synthesized and characterized by spectroscopic and analytical methods to set the stage for latent fingerprint elaboration efficacy testing.